Cell polarization and adhesion in a motile pathogenic protozoan: role and fate ofthe Entamoeba histolytica Gal/GalNAc lectin

详细信息	查看全文 | 推荐本文 |

• 作者：Tavares ; Paulo ; Sansonetti ; Phillipe ; Guill&eacute ; n ; Nancy
• 关键词：Entamoeba histolytica ; pathogenesis ; lectin ; cell adhesion ; cell movement
• 刊名：Microbes and Infection
• 出版年：2000
• 期刊代码：65_12864579
• 类别：imm
• 出版时间：May, 2000
• 卷：2
• 期：6
• 页码：643-649
• 文件大小：355 K

摘要

The human pathogenic protozoan Entamoeba histolytica is a motile cell polarized into a front pseudopod and a rear uroid. The amoebic Gal/GalNAc surface lectin is a major adhesion molecule composed of an immunodominant 170-kDa heavy subunit, mostly extracellular except for a short cytoplasmic tail, and of an extracellular light subunit. The binding of multivalent ligands triggers lectin capping and recruitment to the uroid. The properties of the Gal/GalNAc lectin and its role in amoeba adhesion and uroid polarization are reviewed in the context of the molecular mechanisms underlying cell polarization and locomotion.