Maladie fibroscl茅rosante 脿 IgG4

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• 作者：Marion Hermet¹ ; ^{marionhermet@gmail.com} ; Jean-Louis K&eacute ; m&eacute ; ny² ; Gaë ; lle Guettrot-Imbert¹ ; Isabelle Del&egrave ; vaux¹ ; Olivier Auma&icirc ; tre¹ ; Marc Andr&eacute ; ¹
• 刊名：La Presse M¨|dicale
• 出版年：2012
• 期刊代码：pca289_07554982
• 类别：med
• 出版时间：July-August, 2012
• 卷：41
• 期：7-8
• 页码：682-694
• 文件大小：457 K

摘要

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Key points

rong class="boldFont">IgG4 related diseaserong> (IgG4 RD) was first reported as autoimmune pancreatitis then it was established as a systemic disorder characterised by rong class="boldFont">high blood level of IgG4rong> and rong class="boldFont">fibrosis with rich plasmocytes IgG4+rong> in almost all organs. rong class="boldFont">IgG4 RD is very sensitive to corticosteroid therapyrong>.

IgG4 RD has a high prevalence in eastern countries. Numerous articles on this topic are published and rong class="boldFont">new diagnostic criteriarong> are regularly established. The autoimmune or allergic rong class="boldFont">mechanism of IgG4 RD is still a matter of debaterong>. Interestingly, IgG4 subclass of antibody has anti-inflammatory features.

IgG4 RD is not yet very well characterised in western countries. Whether IgG4 is involved in IgG4 RD, pathophysiology is to be defined. IgG4 RD spontaneously regresses in some cases so rong class="boldFont">indications of treatment are not already well clearrong>.