Synthesis of imidazo[2,1-b]thiazoles linked to an unprotected carbohydrate moiety

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• 作者：Jos&eacute ; Sebastiá ; n Barradas^a ; Marí ; a In&eacute ; s Errea^b ; Norma Beatriz D&rsquo ; Accorso^a ; ^&dagger ; ; ^{norma@qo.fcen.uba.ar}
• 关键词：Heterocycles ; Carbohydrates ; Protective groups ; Imidazo[2 ; 1-b]thiazoles
• 刊名：Carbohydrate Research
• 出版年：2012
• 期刊代码：15_00086215
• 类别：ch
• 出版时间：1 July, 2012
• 卷：355
• 期：Complete
• 页码：79-86
• 文件大小：643 K

摘要

Two series of imidazo[2,1-b]thiazoles substituted on C-3 or C-5 with an unprotected carbohydrate moiety were synthesized. Different protective groups for position 3 of the carbohydrate moiety were tested (acetyl, tert-butyldimethylsilyl (TBDMS), and p-methoxybenzyl (PMB)) and the latter turn out to be the best strategy to obtain the desired products. Full deprotection of the carbohydrate was performed successfully in only one step.