Dynamic contrast enhancement magnetic resonance imaging (DCE-MRI) for differential diagnosis in head and neck cancers

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• 作者：Francis Kar-ho Lee^a ; ^{leekarhof@hotmail.com} ; Ann Dorothy King^a ; ^{king2015@cuhk.edu.hk} ; Brigitte Buig-Yue Ma^b ; ^c ; ^{Brigette@clo.cuhk.edu.hk} ; David Ka-wai Yeung^a ; ^{dkyeung@cuhk.edu.hk}
• 关键词：Dynamic contrast enhancement magnetic resonance imaging (DCE-MRI) ; Squamous cell carcinoma ; Undifferentiated carcinoma and lymphoma ; Diagnosis
• 刊名：European Journal of Radiology
• 出版年：2012
• 期刊代码：93_0720048x
• 类别：med
• 出版时间：April, 2012
• 卷：81
• 期：4
• 页码：784-788
• 文件大小：714 K

摘要

Purpose

To examine the potential of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for differential diagnosis of head and neck cancer.

Methods and materials

DCE-MRI was performed in 26 patients with untreated squamous cell carcinoma (SCC), 28 undifferentiated carcinoma (UD) and 8 lymphoma. DCE-MRI was analyzed with the pharmacokinetic model proposed by Tofts and Kermode to produce the three DCE parameters: k_trans, and . Areas under the curve (AUC) at the initial 60 and 90 s (AUC60 and AUC90) were also recorded. Histogram analysis was conducted to obtain the mean, 25%, 50%, 75%and 95%percentile values and the Kruskal-Wallis test was used to compare the DCE parameters between the three groups of cancer.

Results

k_trans, AUC60 and AUC90 showed significant differences (p < 0.01) between UD/SCC and UD/lymphoma, but not between SCC/lymphoma. The mean AUC90 demonstrated the highest accuracy of 78%(sensitivity of 68%and specificity of 88%) for distinguishing UD and SCC, and the 75%percentile AUC90 provided the highest accuracy of 97%(sensitivity of 100%and specificity of 88.5%) for distinguishing UD and lymphoma.

Conclusions

There are significant differences in the DCE parameters which show the potential for distinguishing UD from SCC or lymphoma.