Pilot clinical trial of 18F-fluorodeoxyglucose positron-emission mammography in the surgical management of breast cancer

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• 作者：Lorraine Tafra ; Zandra Cheng ; Joseph Uddo ; Mary B. Lobrano ; William Stein ; Wendie A. Berg ; Edward Levine ; Irving N. Weinberg ; Deepa Narayanan ; Eric Ross et al.
• 刊名：The American Journal of Surgery
• 出版年：2005
• 期刊代码：9_00029610
• 类别：med
• 出版时间：2005
• 卷：190
• 期：4
• 页码：628-632
• 文件大小：152 K

摘要

Background

High-resolution positron-emission mammography (PEM) is a new device, which allows the imaging of breast tissue. A prospective study was performed to assess the accuracy of PEM in newly diagnosed breast cancer patients.

Methods

In a prospective multicenter study, 44 women with confirmed breast cancers were imaged with a high-resolution PEM scanner (Naviscan PET Systems, Rockville, MD) with 18F-fluorodeoxyglucose. The images were blindly evaluated and were compared with final pathology.

Results

The majority of the index lesions were seen on PEM (89%, 39/44). PEM detected 4 of 5 incidental breast cancers, 3 of which were not seen by any other imaging modalities. Of 19 patients undergoing breast-conserving surgery, PEM correctly predicted 6 of 8 (75%) patients with positive margins and 100%(11/11) with negative margins.

Conclusion

The current PEM device shows promise in detecting breast malignancies and may assist in the planning of adequate partial mastectomy procedures to better ensure negative margins.