Quantitative myocardial distribution volume from dynamic contrast-enhanced MRI

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• 作者：Nathan A. Pack ; Edward V.R. DiBella ; Brent D. Wilson ; Christopher J. McGann
• 关键词：Distribution volume ; Dynamic contrast MRI
• 刊名：Magnetic Resonance Imaging
• 出版年：2008
• 期刊代码：188_0730725x
• 类别：med
• 出版时间：May 2008
• 卷：26
• 期：4
• 页码：532-542
• 文件大小：939 K

摘要

The objective of this study was to investigate if dynamic contrast-enhanced magnetic resonance imaging (MRI) can be used to quantitate the distribution volume (v_e) in regions of normal and infarcted myocardium. v_e reflects the volume of the extracellular, extravascular space within the myocardial tissue. In regions of the heart where an infarct has occurred, the loss of viable cardiac cells results in an elevated v_e compared to normal regions. A quantitative estimate of the magnitude and spatial distribution of v_e is significant because it may provide information complementary to delayed enhancement MRI alone.