- 作者：Pirus Ghadjar ; M.D.&lowast ; ; pirus.ghadjar@insel.ch ; Beat Bojaxhiu&lowast ; ; Mathew Simcock ; M.Sc.&dagger ; ; Dario Terribilini ; Ph.D.&Dagger ; ; Bernhard Isaak ; Ph.D.&Dagger ; ; Philipp Gut ; M.D.&lowast ; ; Patrick Wolfensberger ; M.D.&lowast ; ; Jens O. Brö ; mme ; M.D.&lowast ; ; Andreas Geretschlä ; ger ; M.D.&lowast ; ; Frank Behrensmeier ; M.D.&lowast ; ; Alessia Pica ; M.D.&lowast ; ; Daniel M. Aebersold ; M.D.&lowast ;
- 关键词：Brachytherapy ; Low-dose rate ; High dose rate ; Lip cancer
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2012
- 期刊代码：136_03603016
- 类别：med
- 出版时间：15 July, 2012
- 卷：83
- 期：4
- 页码：1205-1212
- 文件大小：688 K
Purpose
To analyze the outcome after low-dose-rate (LDR) or high-dose-rate (HDR) brachytherapy for lip cancer.Methods and Materials
One hundred and three patients with newly diagnosed squamous cell carcinoma of the lip were treated between March 1985 and June 2009 either by HDR (n = 33) or LDR brachytherapy (n = 70). Sixty-eight patients received brachytherapy alone, and 35 received tumor excision followed by brachytherapy because of positive resection margins. Acute and late toxicity was assessed according to the Common Terminology Criteria for Adverse Events 3.0.
Results
Median follow-up was 3.1 years (range, 0.3-23 years). Clinical and pathological variables did not differ significantly between groups. At 5 years, local recurrence-free survival, regional recurrence-free survival, and overall survival rates were 93%, 90%, and 77%. There was no significant difference for these endpoints when HDR was compared with LDR brachytherapy. Forty-two of 103 patients (41%) experienced acute Grade 2 and 57 of 103 patients (55%) experienced acute Grade 3 toxicity. Late Grade 1 toxicity was experienced by 34 of 103 patients (33%), and 5 of 103 patients (5%) experienced late Grade 2 toxicity; no Grade 3 late toxicity was observed. Acute and late toxicity rates were not significantly different between HDR and LDR brachytherapy.
Conclusions
As treatment for lip cancer, HDR and LDR brachytherapy have comparable locoregional control and acute and late toxicity rates. HDR brachytherapy for lip cancer seems to be an effective treatment with acceptable toxicity.