Effects of vitamin D deficiency in critically ill surgical patients

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• 作者：Lisa Flynn ; M.D.^a ; Lisa Hall Zimmerman ; Pharm.D.^b ; Kelly McNorton ; Pharm.D.^b ; Mortimer Dolman ; M.D.^c ; James Tyburski ; M.D.^a ; Alfred Baylor ; M.D.^a ; Robert Wilson ; M.D.^a ; Heather Dolman ; M.D.^a ; ^{hdolman@med.wayne.edu}
• 关键词：Vitamin D ; Deficiency ; Surgical intensive care unit ; Critical illness
• 刊名：The American Journal of Surgery
• 出版年：2012
• 期刊代码：9_00029610
• 类别：med
• 出版时间：March, 2012
• 卷：203
• 期：3
• 页码：379-382
• 文件大小：145 K

摘要

Background

The incidence of vitamin D deficiency in critically ill patients is reported to be up to 50%, with a 3-fold increase in predicted mortality, but limited data exist concerning vitamin D deficiency in critically ill surgical patients.

Methods

Sixty-six adult surgical intensive care unit patients who had 25-hydroxyvitamin D serum levels evaluated from January 2010 to February 2011 were prospectively identified. Patients were divided into groups according to vitamin D level (<20 vs 鈮?0 ng/mL).

Results

Of the 66 patients evaluated, 49 (74%) had vitamin D levels < 20 ng/mL, and 17 (26%) had vitamin D levels 鈮?20 ng/mL. Patients with vitamin D levels < 20 versus 鈮?20 ng/mL had longer lengths of hospital stay. Lengths of intensive care unit stay were clinically longer, although not significant. Infection rates tended to be higher (P = .09), and a higher incidence of sepsis was seen in the patients with vitamin D levels < 20 ng/mL.

Conclusions

Vitamin D levels < 20 ng/mL have a significant impact on length of stay, organ dysfunction, and infection rates. More data are needed on the value of supplementation to improve these outcomes.