Synthesis, characterization, antibacterial activity, and interaction with DNA of the vanadyl-enrofloxacin complex

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• 作者：Eleni K. Efthimiadou ; Nikos Katsaros ; Alex ; ra Karaliota ; George Psomas
• 关键词：Enrofloxacin ; Quinolones ; Vanadyl complex ; Biological activity ; Interaction with calf-thymus DNA ; MIC
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2007
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：1 March 2007
• 卷：17
• 期：5
• 页码：1238-1242
• 文件大小：275 K

摘要

The neutral mononuclear vanadyl complex with the quinolone antibacterial drug enrofloxacin has been prepared and characterized with physicochemical and spectroscopic techniques and molecular mechanics calculations. The interaction of the complex with calf-thymus DNA has also been investigated and the antimicrobial activity has been evaluated against three different microorganisms.