Transition metal complexes with the quinolone antibacterial agent pipemidic acid: Synthesis, characterization and biological activity
- 作者：Eleni K. Efthimiadou ; Yiannis Sanakis ; Nikos Katsaros ; Alex ; ra Karaliota ; George Psomas
- 关键词：Pipemidic acid ; Quinolones ; Metal complexes ; Spectroscopic study ; Interaction with CT DNA ; Antibacterial activity
- 刊名：Polyhedron
- 出版年：2007
- 期刊代码：87_02775387
- 类别：ch
- 出版时间：25 March 2007
- 卷：26
- 期：5
- 页码：1148-1158
- 文件大小：422 K
摘要
Nine new mononuclear metal complexes of the quinolone antibacterial agent pipemidic acid (= HPPA) with VO2+, Mn2+, Fe3+, Co2+, Ni2+, Zn2+, , Cd2+ and have been prepared and characterized with physicochemical and spectroscopic techniques. In all the complexes, pipemidic acid acts as a bidentate deprotonated ligand bound to the metal through the pyridone oxygen atom and one carboxylate oxygen atom. All the complexes are six-coordinate and the geometry round the metal atom can be described as a slightly distorted octahedron. For VO(PPA)2(H2O), the axial position, trans to the vanadyl oxygen, is occupied by one pyridone oxygen atom. Molecular mechanics calculations in the gas state have been performed in order to propose a model for the structure of the Fe3+, VO2+ and complexes. The antimicrobial activity of the complexes has been tested on three different microorganisms. The investigation with diverse spectroscopic techniques of the interaction of the complexes with calf-thymus DNA has shown that the complexes can be bound to DNA resulting in a B → A DNA transition.