Mononuclear metal complexes of the second-generation quinolone antibacterial agent enrofloxacin: Synthesis, structure, antibacterial activity and interaction with DNA

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• 作者：Eleni K. Efthimiadou ; Alex ; ra Karaliota ; George Psomas
• 关键词：Enrofloxacin ; Quinolones ; Metal complexes ; Molecular modeling ; Interaction with calf-thymus DNA ; MIC
• 刊名：Polyhedron
• 出版年：2008
• 期刊代码：87_02775387
• 类别：ch
• 出版时间：25 April 2008
• 卷：27
• 期：6
• 页码：1729-1738
• 文件大小：444 K

摘要

Seven novel metal complexes of the second-generation quinolone antibacterial agent enrofloxacin with Mn²⁺, Fe³⁺, Co²⁺, Ni²⁺, Zn²⁺, Cd²⁺ and kWA" alt="View the MathML source" title="View the MathML source" align="absbottom" border="0" height=19 width="48"/> have been prepared and characterized with physicochemical methods and infrared, UV–Vis and nuclear magnetic resonance spectroscopies. In the resultant complexes, enrofloxacin acts as a bidentate deprotonated ligand bound to the metal through the pyridone oxygen and one carboxylate oxygen. The central metal atoms are six-coordinate with slightly distorted octahedral geometry. Molecular modeling calculations have been performed in order to propose a model for the structure of Mn²⁺, Fe³⁺ and kWA" alt="View the MathML source" title="View the MathML source" align="absbottom" border="0" height=19 width="48"/> complexes. The investigation of the interaction of the complexes with calf-thymus DNA has been performed with UV and circular dichroism spectroscopies. The antimicrobial activity of the complexes has been tested on three different microorganisms. The complexes exhibit better or equal inhibition in comparison to free enrofloxacin.