Neutral mononuclear dioxomolybdenum(VI) and dioxouranium(VI) complexes of oxolinic acid: Characterization and biological evaluation

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• 作者：Alketa Tarushi ; Eleni K. Efthimiadou ; Petros Christofis ; George Psomas
• 关键词：Quinolones ; Oxolinic acid ; Dioxomolybdenum(VI) complexes ; Uranyl(VI) complexes ; Interaction with calf-thymus DNA ; MIC
• 刊名：Inorganica Chimica Acta
• 出版年：2007
• 期刊代码：40_00201693
• 类别：ch
• 出版时间：1 November 2007
• 卷：360
• 期：14
• 页码：3978-3986
• 文件大小：276 K

摘要

The interaction of the first-generation quinolone antibacterial drug oxolinic acid (Hoxo) with the dioxomolybdenum(VI) and dioxouranim(VI) ions leads to the formation of the neutral mononuclear complexes MoO₂(oxo)₂ and UO₂(oxo)₂, respectively. The structure of the complexes has been characterized physicochemically and spectroscopically. The lowest energy model structure of the complexes has been determined with molecular modeling calculations. The antimicrobial activity of the complexes has been evaluated against three different microorganisms. The interaction of the complexes with calf-thymus DNA has been investigated with electronic and circular dichroism spectroscopies.