Synthesis, characterization and DNA-binding of the mononuclear dioxouranium(VI) complex with ciprofloxacin
- 作者：George Psomas ; Alketa Tarushi ; Eleni K. Efthimiadou
- 关键词：Ciprofloxacin ; Quinolones ; Uranyl(VI) complex ; Molecular modelling ; Interaction with calf-thymus DNA
- 刊名：Polyhedron
- 出版年：2008
- 期刊代码：87_02775387
- 类别：ch
- 出版时间：20 January 2008
- 卷：27
- 期：1
- 页码：133-138
- 文件大小：199 K
摘要
The mononuclear complex of the second-generation quinolone antibacterial agent ciprofloxacin with 
kWA" alt="Click to view the MathML source" align="absbottom" border="0" height=19 width=48> has been prepared and characterized with physicochemical and spectroscopic techniques. In this complex, ciprofloxacin acts as a bidentate deprotonated ligand bound to the metal through the pyridone oxygen and one carboxylate oxygen. The central U(VI) atom is six-coordinate and a slightly distorted octahedral geometry is proposed. The lowest energy model structure of the complex has been determined with molecular modelling calculations. The biological activity of the complex has been evaluated by examining its ability to bind to calf-thymus DNA.