Size dependent bioaccumulation and ecotoxicity of gold nanoparticles in an endobenthic invertebrate: The Tellinid clam Scrobicularia plana

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• 作者：Jin-Fen Pan^a ; ^b ; Pierre-Emmanuel Buffet^b ; Laurence Poirier^b ; Claude Amiard-Triquet^b ; ^{amiard-triquet-c@univ-nantes.fr} ; Douglas Gilliland^c ; Yolaine Joubert^b ; Paul Pilet^f ; Marielle Guibbolini^d ; Christine Risso de Faverney^d ; Mich&egrave ; le Romé ; o^d ; Eugenia Valsami-Jones^e ; Catherine Mouneyrac^b ; ^g
• 关键词：Gold nanoparticles ; Scrobicularia plana ; Bioavailability ; Biomarkers
• 刊名：Environmental Pollution
• 出版年：2012
• 期刊代码：28_02697491
• 类别：env
• 出版时间：September, 2012
• 卷：168
• 期：Complete
• 页码：37-43
• 文件大小：793 K

摘要

Gold nanoparticles (AuNPs) have important technological applications resulting in an increased potential for release to the environment, and a greater possibility of toxicological effects. The marine bivalve Scrobicularia plana was exposed to AuNPs of size 5, 15 and 40 nm during a 16 d laboratory exposure at 100 渭g Au L^鈭?. After exposure to AuNPs forming aggregates (>700 nm), the clams accumulated Au in their soft tissues. Biochemical (biomarkers) and behavioral (burrowing and feeding) responses were investigated. Au NPs were responsible of metallothionein induction (5, 40 nm), increased activities of catalase (15, 40 nm) and superoxide dismutase (40 nm) and of glutathione S-transferase by the three sizes of AuNPs indicating defense against oxidative stress. Exposure to AuNPs impaired burrowing behavior. However, it must be underlined that these effects were observed at a dose much higher than expected in the environment.