Cyclodextrins selectively modified on both rims using an O-3-debenzylative post-functionalisation, a consequence of the Sorrento meeting

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• 作者：Maxime Guitet^a ; Sé ; gol&egrave ; ne Adam de Beaumais^a ; Yves Blé ; riot^b ; Boris Vauzeilles^c ; Yongmin Zhang^a ; Mickaë ; l Mé ; nand^a ; Matthieu Sollogoub^a ; ^{matthieu.sollogoub@upmc.fr}
• 关键词：Cyclodextrin ; Deprotection ; Regioselective ; Chemoselective ; Post-functionalisation
• 刊名：Carbohydrate Research
• 出版年：2012
• 期刊代码：15_00086215
• 类别：ch
• 出版时间：15 July, 2012
• 卷：356
• 期：Complete
• 页码：278-281
• 文件大小：631 K

摘要

A de-O-benzylation reaction induced by I₂-Et₃SiH and developed by Iadonisi et al. on mono- and disaccharides was applied to per- or polybenzylated 伪-cyclodextrins to furnish compounds deprotected at position 3 of all sugar units. This methodology allows the straightforward post-functionalisation of the secondary rim of cyclodextrins already functionalised on their primary rim.