Expression, tissue localization and synergy of antimicrobial peptides and proteins in the immune response of the oyster Crassostrea gigas

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• 作者：Paulina Schmitt^a ; ^b ; ¹ ; Julien de Lorgeril^a ; Yannick Gueguen^a ; ² ; Delphine Destoumieux-Garzó ; n^c ; Evelyne Bach&egrave ; re^a ; ^{ebachere@ifremer.fr}
• 关键词：Pacific oyster ; Bivalve mollusk ; Innate immunity ; Bactericidal/permeability-increasing protein ; Proline-rich peptide ; Defensin ; Vibrio
• 刊名：Developmental and Comparative Immunology
• 出版年：2012
• 期刊代码：35_0145305x
• 类别：abs
• 出版时间：July, 2012
• 卷：37
• 期：3-4
• 页码：363-370
• 文件大小：454 K

摘要

Diverse families of antimicrobial peptides and proteins have been described in oysters. We investigated here how antimicrobials are involved in the immune response against a pathogenic strain of Vibrio splendidus. Oyster antimicrobials were shown to display a wide variety of expression profiles in hemocyte populations and tissues. Oyster defensins are constitutively expressed in specific tissues such as mantle (Cg-Defm) or hemocytes (Cg-Defhs), while Cg-BPI is inducible and Cg-Prp appears down-regulated in hemocytes upon infection. The migratory behavior of hemocytes that express the different antimicrobials was found to be involved in the oyster response to a pathogenic Vibrio infection. Indeed, it contributes to colocalize several antimicrobials that were shown here to have synergistic activities. We propose that such a synergy, which was evidenced both within and between families of antimicrobials, might compensate for the low concentration of antimicrobials in oyster tissues.