Calcium phosphate porous pellets as drug delivery systems: Effect of drug carrier composition on drug loading and in vitro release
- 作者：Hiva Baradari ; hiva.baradari@etu.unilim.fr ; Chantal Damia ; Maggy Dutreih-Colas ; Etienne Laborde ; Nathalie Pé ; cout ; Eric Champion ; Dominique Chulia ; Marylè ; ne Viana
- 关键词：Hydroxyapatite ; Beta tricalcium phosphate ; Porous pellets ; Drug delivery system ; Ibuprofen
- 刊名：Journal of the European Ceramic Society
- 出版年：2012
- 期刊代码：53_09552219
- 类别：ms
- 出版时间：August, 2012
- 卷：32
- 期：11
- 页码：2679-2690
- 文件大小：1405 K
摘要
Drug loaded porous calcium phosphate bone substitutes are studied for targeted drug delivery applications. In this study, porous hydroxyapatite and beta-tricalcium phosphate pellets were investigated as anti-inflammatory drug carriers and their ibuprofen adsorption and release properties were compared. While the adsorption equilibrium time of 1 h was obtained for both pellets, hydroxyapatite pellets showed a higher adsorption capacity than beta-tricalcium phosphate. The physico-chemical characterisations of loaded pellets confirmed an ibuprofen reversible physisorption on both hydroxyapatite and beta-tricalcium phosphate pellets. Moreover, higher adsorption capacity of hydroxyapatite was attributed to their physical differences. The in vitro ibuprofen release evaluation showed 100%release of ibuprofen from both hydroxyapatite and beta-tricalcium phosphate pellets which was found to be compatible with the obtained interactions between the pellets and ibuprofen.