Dietary fat ingestion activates 尾-endorphin neurons in the hypothalamus
- 作者：Shigenobu Matsumura ; sigenobu@kais.kyoto-u.ac.jp ; Ai Eguchi ; Yoko Okafuji ; Sotaro Tatsu ; Takafumi Mizushige ; Satoshi Tsuzuki ; Kazuo Inoue ; Tohru Fushiki
- 关键词：POMC ; pro-opiomelanocortin ; GLX ; glosspharyngeal nerve transection surgery
- 刊名：FEBS Letters
- 出版年：2012
- 期刊代码：70_00145793
- 类别：bio
- 出版时间：24 April, 2012
- 卷：586
- 期：8
- 页码：1231-1235
- 文件大小：659 K
摘要
The opioid system regulates food choice, consumption, and reinforcement processes, especially for palatable meals such as fatty food. 尾-Endorphin is known as an endogenous opioid peptide produced in neurons of the hypothalamus. In this study, we found that Intralipid (fat emulsion) ingestion increased c-fos expression in 尾-endorphin neurons. However, intragastric infusion of Intralipid only slightly increased c-fos expression 2 h after infusion. Further, dissection of glossopharyngeal nerve, innervating posterior tongue taste buds, partially but significantly decreased the Intralipid-induced c-fos expression. These results indicate that mainly the orosensory stimulation from fat may activate 尾-endorphin neurons, thereby promoting 尾-endorphin release.