Synthesis and characterization of poly(antioxidant 尾-amino esters) for controlled release of polyphenolic antioxidants
- 作者：Paritosh P. Wattamwar ; Dipti Biswal ; David B. Cochran ; Adam C. Lyvers ; Richard E. Eitel ; Kimberly W. Anderson ; J. Zach Hilt ; Thomas D. Dziubla ; dziubla@engr.uky.edu
- 关键词：Antioxidant polymers ; Polyphenols ; Oxidative stress ; Curcumin ; Biocompatibility
- 刊名：Acta Biomaterialia
- 出版年：2012
- 期刊代码：1_17427061
- 类别：ce
- 出版时间：July, 2012
- 卷：8
- 期：7
- 页码：2529-2537
- 文件大小：1299 K
摘要
Attenuation of cellular oxidative stress, which plays a central role in biomaterial-induced inflammation, provides an exciting opportunity to control the host tissue response to biomaterials. In the case of biodegradable polymers, biomaterial-induced inflammation is often a result of local accumulation of polymer degradation products, hence there is a need for new biomaterials that can inhibit this response. Antioxidant polymers, which have antioxidants incorporated into the polymer backbone, are a class of biomaterials that, upon degradation, release active antioxidants, which can scavenge free radicals and attenuate oxidative stress, resulting in improved material biocompatibility. In this work, we have synthesized poly(antioxidant 尾-amino ester) (PA尾AE) biodegradable hydrogels of two polyphenolic antioxidants, quercetin and curcumin. The degradation characteristics of PA尾AE hydrogels and the antioxidant activity of PA尾AE degradation products were studied. Treatment of endothelial cells with PA尾AE degradation products protected cells from hydrogen-peroxide-induced oxidative stress.