Nutritional and biochemical parameters associated with 6-year change in bone mineral density in community-dwelling Japanese women aged 69 years and older: The Muramatsu Study

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• 作者：Kazutoshi Nakamura ; M.D.^a ; ^{kazun@med.niigata-u.ac.jp} ; Mari Oyama ; M.D.^a ; Toshiko Saito ; Ph.D.^b ; Rieko Oshiki ; Ph.D.^c ; Ryosaku Kobayashi ; Ph.D.^c ; Tomoko Nishiwaki ; Ph.D.^d ; Mitsue Nashimoto ; Ph.D.^d ; Yasuo Tsuchiya ; Ph.D.^a
• 关键词：Albumin ; Bone density ; Cohort studies ; Elderly ; Nutrition ; Vitamin D
• 刊名：Nutrition
• 出版年：2012
• 期刊代码：81_08999007
• 类别：abs
• 出版时间：April, 2012
• 卷：28
• 期：4
• 页码：357-361
• 文件大小：136 K

摘要

Objective

Predictors of bone loss in elderly Asian women have been unclear. This cohort study aimed to assess lifestyle, nutritional, and biochemical predictors of bone loss in elderly Japanese women.

Methods

Subjects included 389 community-dwelling women aged 69 y and older from the Muramatsu cohort initiated in 2003; follow-up ended in 2009. We obtained data on physical characteristics, osteoporosis treatment (with bisphosphonates or selective estrogen receptor modulators), physical activity, calcium intake, serum 25-hydroxyvitamin D, undercarboxylated osteocalcin, serum albumin, and bone turnover markers as predictors. The outcome was a 6-y change in forearm BMD (螖BMD). Osteoporosis treatment was coded as 0 for none, 1 for sometimes, and 2 for always during the follow-up period. Stepwise multiple linear regression analysis was used to identify independent predictors of 螖BMD.

Results

Mean age of the subjects was 73.3 y. Mean values of 螖BMD and 螖weight were 鈭?.019 g/cm² (鈭?.8%) and 鈭?.2 kg, respectively. Stepwise multiple linear regression analysis revealed baseline BMD (尾 = 鈭?.137, P < 0.0001), osteoporosis treatment (尾 = 0.0068, P = 0.0105), serum albumin levels (尾 = 0.0122, P = 0.0319), and 螖weight (尾 = 0.0015, P = 0.0009) as significant independent predictors of 螖BMD. However, none of the other nutritional or biochemical indices were found to be significant predictors of 螖BMD.

Conclusions

Our findings indicate that adequate general nutrition and appropriate osteoporosis medication, rather than specific nutritional regimens, may be effective in preventing bone loss in elderly women.