Simultaneous determination of ascorbic acid, dopamine and uric acid using high-performance screen-printed graphene electrode
- 作者：Jianfeng Ping ; Jian Wu ; Yixian Wang ; Yibin Ying ; ybying@zju.edu.cn
- 关键词：IL ; ionic liquid ; BPFP ; n-butylpyridinium hexafluorophosphate ; GO ; graphite oxide ; GNO ; graphene oxide ; CRGNO ; chemically reduced graphene oxide ; SPE ; screen-printed electrode ; SPE* ; screen-printed electrode using commercially available conductive graphit
- 刊名：Biosensors and Bioelectronics
- 出版年：2012
- 期刊代码：12_09565663
- 类别：ch
- 出版时间：15 April, 2012
- 卷：34
- 期：1
- 页码：70-76
- 文件大小：1052 K
摘要
A disposable and sensitive screen-printed electrode using an ink containing graphene was developed. This electrode combined the advantages of graphene and the disposable characteristic of electrode, which possessed wide potential window, low background current and fast electron transfer kinetics. Compared with the electrodes made from other inks, screen-printed graphene electrode (SPGNE) showed excellent electrocatalytic activity for the oxidation of ascorbic acid (AA), dopamine (DA), and uric acid (UA). Three well-defined sharp and fully resolved anodic peaks were found at the developed electrode. Differential pulse voltammetry was used to simultaneous determination of AA, DA, and UA in their ternary mixture. In the co-existence system of these three species, the linear response ranges for the determination of AA, DA, and UA were 4.0-4500 渭M, 0.5-2000 渭M, and 0.8-2500 渭M, respectively. The detection limits (S/N = 3) were found to be 0.95 渭M, 0.12 渭M, and 0.20 渭M for the determination of AA, DA, and UA, respectively. Furthermore, the SPGNE displayed high reproducibility and stability for these species determination. The feasibility of the developed electrode for real sample analysis was investigated. Results showed that the SPGNE could be used as a sensitive and selective sensor for simultaneous determination of AA, DA, and UA in biological samples, which may provide a promising alternative in routine sensing applications.