Asymmetric transfer hydrogenation of ketones catalyzed by ruthenium(II) complexes bearing a chiral phosphinoferrocenyloxazoline ligand

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• 作者：Cesar A. Madrigal ; Almudena Garc&#xed ; a-Fern&#xe1 ; ndez ; Jos&#xe9 ; Gimeno ; Elena Lastra
• 关键词：Ruthenium(II) catalysts ; Asymmetric hydrogen transfer ; Ferrocenyl oxazoline ; Ferrocenylphosphine ; Indenyl complexes ; Arene complexes
• 刊名：Journal of Organometallic Chemistry
• 出版年：2008
• 期刊代码：64_0022328x
• 类别：ch
• 出版时间：15 July 2008
• 卷：693
• 期：15
• 页码：2535-2540
• 文件大小：228 K

摘要

The catalytic activity in asymmetric transfer hydrogenation of ketones using octahedral and half-sandwich (η⁵-indenyl and η⁶-arene) ruthenium(II) complexes containing the chiral ligand (4S)-2-[(S_p)-2-(diphenylphosphino)ferrocenyl]-4-(isopropyl)oxazoline (FcPN) has been explored. Catalytic studies with complex fac-[RuCl₂{η²(P,N)-FcPN}(PMe₃)₂] (1) show excellent TOF values (9600 h⁻¹). Experiments in the presence of free FcPN, which lead to an increase in conversion rates and ee values when the catalyst is complex [Ru(η⁵-C₉H₇){κ²(P,N)-FcPN}(PPh₃)][PF₆] (4) have been carried out. The characterization of the new complexes mer–trans-[RuCl₂{P(OMe)₃}₂{κ²(P,N)-FcPN}] and of the water-soluble complexes fac- and mer–trans-[RuCl₂(PTA)₂{κ²(P,N)-FcPN}] is also reported.