- 作者：Ariel Fuentes ; fuentesarielster@gmail.com ; Alex Muñ ; oz ; Ricardo Pommer ; Begoñ ; a Argü ; ello ; Andrea Galleguillos ; Andrea Torres ; Cristian Jesam
- 关键词：AMH ; anti-Mü ; llerian hormone ; FF ; Follicular fluid ; CP ; Cotinine positive ; CN ; Cotinine negative ; CS ; Current smoker ; ES ; Ex smoker ; BS ; Never smoker
- 刊名：Chemosphere
- 出版年：2012
- 期刊代码：15_00456535
- 类别：env
- 出版时间：July, 2012
- 卷：88
- 期：4
- 页码：403-406
- 文件大小：230 K
Background
Several reports indicate that women who smoke have an increased risk of failure to conceive compared with their non-smoker counterparts. Here, we assessed the effect of smoking during the Assisted Reproduction Therapy (ART) on a potential marker of ovarian reserve, anti-m眉llerian hormone (AMH) in the follicular fluid (FF).Materials and Methods
This was a cohort prospective study to assess the association between cigarette smoking and AMH concentrations in FF in fifty-six women undergoing their first ART cycle. Self-reported smoking status over time was also collected through personal interview. The main outcome measured was the association between current smoking and AMH concentrations in FF. Smoking status was assessed by FF cotinine concentrations. Analysis of covariance was performed to test statistical interaction between the main outcome and confounders.
Results
The mean concentration of AMH in follicular fluid was significantly decreased among smokers (1.02卤0.14 vs. 1.74卤0.15, P<0.05). No statistical interaction was found between this difference in AMH concentrations and confounders like age and BMI. Thus, our data support the idea that AMH is decreased in active smokers across the fertile age.
Conclusions
The hypothesis of decreased AMH concentration in follicular fluid in female smokers was confirmed. The mechanisms through which cigarette smoking induces this fall in AMH are unknown and additional research is needed to improve our comprehension of the negative impact of smoking on ART outcomes.