• 作者：Melchor Rodrí ; guez Gaspar^a ; ^{melrodgaspar@hotmail.com} ; Juan Marí ; a Borregero Leó ; n^c ; Emilio Gonzá ; lez Reimers^a ; Juan-José ; Viñ ; a Rodrí ; guez^a ; Miguel Serrano Garcí ; a^b ; Francisco Santolaria Ferná ; ndez^a
• 关键词：Factores de riesgo vascular ; Trombosis venosa retiniana ; Embolia arterial retiniana ; Neuropat&iacute ; a ó ; ptica isqué ; mica anterior
• 刊名：Medicina Cl铆nica
• 出版年：2010
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：6 February 2010
• 卷：134
• 期：3
• 页码：95-100
• 文件大小：179 K

Background and objective

The aim of the present study is to define the risk factors associated with different retinal occlusive diseases, such as retinal venous thrombosis, arterial emboli and ischaemic anterior optic neuritis. Patients with any of these entities entered the study.

Patients and method

A cross-sectional study on 284 consecutive subjects, aged 25鈥?3, who were initially attended at the ophthalmology unit and then sent to the internal medicine unit.

Results

We included 284 patients, 52%men, 48%women, aged 62卤12 years (range 25鈥?3). Retinal vein thrombosis was observed in 66%(IC 95%: 60.4鈥?1,5), followed by anterior ischemic optic neuropathy in 21%(IC 95%: 16, 1鈥?5,8) and arterial embolism in 11%(IC 95%: 7,29鈥?4,7). Vascular risk factors were frequently recorded, especially hypertension in 50%(IC 95%: 44, 0鈥?5,9) and metabolic syndrome in 39%(IC 95%: 33,2鈥?4,7). Venous thrombosis showed an association with hypertension and with left ventricular hypertrophy, especially central vein thrombosis (54%, p<0.009). Among those with arterial embolism obesity was less frequently observed (p=0.04), but these patients showed significantly (p<0.001) more vascular bruits, carotideal atheromatous plaques and extraocular vascular disease. Anterior optic ischaemic neuritis was significantly associated with obesity, overweight, and diabetes. No differences were observed regarding inflammatory markers (CRP, TNF alpha, IL-6 and IL-10) among the different retinal occlusive diseases analysed.

Conclusions

Occlusive retinal diseases are associated with vascular risk factors, but the association is specific for each entity.