Cough induced by losartan with resolution after substitution with enalapril

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• 作者：Simin Dashti-Khavidaki ; Toktam Faghihi ; Farrokhlegha Ahmadi ; Hossein Khalili
• 关键词：cough ; losartan ; enalapril ; angiotensin-converting enzyme inhibitor ; angiotensin-receptor blockers
• 刊名：Clinical Therapeutics
• 出版年：2008
• 期刊代码：65_01492918
• 类别：med
• 出版时间：March 2008
• 卷：30
• 期：3
• 页码：548-551
• 文件大小：78 K

摘要

Introduction: Cough is an adverse event associated with the angiotensin-converting enzyme (AA inhibitor drugs. ACE inhibitor-induced cough is believed to be related to the accumulation of bradykinin,substance P,and prostaglandins resulting from the inhibition of ACE.Angiotensin-receptor blockers (AARBs) do not have any effect on ACE and theoretically might not cause cough. Therefore, a proposed option in patients suffering with ACE inhibitor -induced cough is to try an ARB.However,this report describes the reverse: a case of lo osarta an-iin nduced cough th hat co om mple etely resolved after it was substituted with an ACE inhibitor, enalapril.