The Baeyer–Villiger reaction on heterogeneous catalysts

详细信息	查看全文 | 推荐本文 |

• 作者：Cé ; sar Jimé ; nez-Sanchidriá ; n ; José ; Rafael Ruiz
• 关键词：Aldol reaction ; CF₃-enone ; Acetone ; Organocatalysis ; l-Proline derivatives
• 刊名：Tetrahedron
• 出版年：2008
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：25 February 2008
• 卷：64
• 期：9
• 页码：2011-2026
• 文件大小：2060 K

摘要

An unexpected enantioselective 1,2-aldol reaction of acetone with α,β-unsaturated trifluoromethylketone catalyzed by l-proline derivative was described. The absolute configuration of the resulting chiral product was assigned based on a single crystal X-ray diffraction analysis. Structure–reactivity study of this organocatalytic system was briefly discussed. A reaction mechanism was tentatively postulated.