Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy

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• 作者：Kakulavarapu V. Rama Rao^a ; Michael D. Norenberg^a ; ^b ; ^c ; ^{mnorenbe@med.miami.edu}
• 关键词：Ammonia ; Astrocytes ; Brain edema ; Energy metabolism ; Hepatic encephalopathy ; Mitochondrial permeability transition ; Oxidative stress
• 刊名：Neurochemistry International
• 出版年：2012
• 期刊代码：120_01970186
• 类别：bio
• 出版时间：June, 2012
• 卷：60
• 期：7
• 页码：697-706
• 文件大小：506 K

摘要

One proposed mechanism for acute and chronic hepatic encephalopathy (HE) is a disturbance in cerebral energy metabolism. It also reviews the current status of this mechanism in both acute and chronic HE, as well as in other hyperammonemic disorders. It also reviews abnormalities in glycolysis, lactate metabolism, citric acid cycle, and oxidative phosphorylation as well as associated energy impairment. Additionally, the role of mitochondrial permeability transition (mPT), a recently established factor in the pathogenesis of HE and hyperammonemia, is emphasized. Energy failure appears to be an important pathogenetic component of both acute and chronic HE and a potential target for therapy.