• 作者：Daniel Sá ; nchez Cano^a ; ^{danifilax@gmail.com} ; Ricardo Ruiz-Villaverde^b ; M. Carmen Olvera Porcel^c ; José ; Luis Callejas Rubio^d ; Carlos Cardeñ ; a Pé ; rez^e ; Marí ; a Gó ; mez Garcí ; a^f ; Jorge Gonzá ; lez Calvin^e ; Norberto Ortego Centeno^d
• 关键词：Enfermedad de Crohn ; Osteoporosis ; OPG ; RANKL ; sTNF-RI
• 刊名：Gastroenterolog铆a y Hepatolog铆a
• 出版年：2011
• 期刊代码：pca167_02105705
• 类别：med
• 出版时间：January 2011
• 卷：34
• 期：1
• 页码：3-9
• 文件大小：142 K

Introduction

Patients with Crohn's disease are at risk of developing osteoporosis, a disease in which the inflammatory process seems to be gaining importance. We performed a cross-sectional study to evaluate bone metabolism, osteoclastogenic factors [receptor activator of NF-kB ligand (RANK-L) and osteoprotegerin (OPG)] and soluble tumor necrosis factor-伪 receptor I (sTNF-RI) in patients with Crohn's disease and to correlate the findings with the degree of disease activity.

Method

Sixty-four patients with Crohn's disease from the province of Granada (Spain) were included in this study. Bone mineral density (BMD) was studied through dual X-ray absorptiometry. Immunoassay was used to assess markers of bone formation [bone alkaline phosphatase (bALP) and osteocalcin (OC)] and bone resorption [tartrate resistant acid phosphatase (TRAP) and carboxyterminal telopeptide of type I procollagen (CTX)] as well as RANKL, OPG and sTNF-RI.

Results

The percentage of patients with a Z-score 鈮?2 in the femoral neck or lumbar spine was 20.3%and was higher in patients with active disease, although this difference was not significant. This percentage was only higher in patients receiving corticosteroids (11.1 vs. 9.1%; P = .001). Patients with the highest disease activity had higher TRAP levels. No significant differences were found in BMD but significant differences were found in TRAP levels with respect to C-reactive protein concentrations. No association was found between levels of OPG, RANKL and sTNF-RI and BMD or disease activity.

Conclusions

A substantial proportion of our patients had low BMD. Levels of bone turnover markers suggested higher bone resorption, possibly in relation to disease activity, without a compensatory increase in bone formation.