• 作者：Carmen Gutié ; rrez Castillo^a ; ^{mcgc_1981@hotmail.com} ; Enrique Monerris Garcí ; a^a ; Marí ; a Dolores Duran^b ; Manuela Sancho Mestre^a ; Juan Ram&#243 ; n Gras^a
• 关键词：Papiloma ; Laringe ; HPV ; Lá ; ser CO2
• 刊名：Acta Otorrinolaringol贸gica Espa帽ola
• 出版年：2010
• 期刊代码：pca34_00016519
• 类别：med
• 出版时间：November-December 2010
• 卷：61
• 期：6
• 页码：422-427
• 文件大小：338 K

lass="h4">Objectives

The study goal was to evaluate the efficacy of CO₂ laser surgery in the treatment of laryngeal papillomatosis. We analysed several parameters such as gender, average age, relapse rate and viral serotype.

lass="h4">Material and methods

A total of 26 diagnosed patients were included in this retrospective descriptive review. All of them were treated with CO₂ laser for laryngeal papillomas between 1995 and 2010.

lass="h4">Results

This pathology was more prevalent in males (65.5%), with a slight predominance of a single larynx localisation over multiple lesion locations. Human papillomavirus (HPV) DNA was detected in 75.8%of the cases; genotypes 6 and 11 prevailed. Of the patients in this review, 44.8%relapsed; the relapse average was 2鈥? episodes per patient. A total of 20.7%of cases were in remission (no relapse in the last 2 months); 34.5%, clearing (no apparent relapse in the last 3 years); and 41.3%in the healing stage (without relapse in the last 5 years). There was only one case that showed malignancy.

lass="h4">Conclusion

Papillomatosis is characterised as a pathology with an unpredictable course and with a low probability of malignancy. CO₂ laser surgery has meant a revolution in symptomatic treatment, but there is presently no curative treatment.