Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo

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• 作者：Yajun Yang^a ; ^b ; Lianfeng Zhang^a ; Xiaoxu Fan^a ; Chuan Qin^a ; ^b ; Jiangning Liu^a ; ^{ljn_zb03038@126.com}
• 关键词：Enterovirus 71 ; Geraniin ; Drug ; Mouse model
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：15 March, 2012
• 卷：22
• 期：6
• 页码：2209-2211
• 文件大小：573 K

摘要

Human enterovirus 71 infection causes hand, foot and mouth disease in children under 6 years of age and has caused mortalities in large-scale outbreaks in the Asia-Pacific region. No effective vaccine or antiviral drugs currently exist against enterovirus 71 in the clinic. In this study, we investigated the antiviral effect of geraniin on enterovirus 71 both in vitro and in vivo. The results showed that geraniin effectively inhibited virus replication in rhabdomyosarcoma cells with an IC₅₀ of 10 渭g/ml. Moreover, geraniin treatment of mice that were challenged with a lethal dose of enterovirus 71 resulted in a reduction of mortality, relieved clinical symptoms, and inhibited virus replication in muscle tissues. The results suggest that geraniin may be used as a potential drug for anti-enterovirus 71.