Environmentally induced epigenetic transgenerational inheritance of phenotype and disease
- 作者：Carlos Guerrero-Bosagna ; catelo@wsu.edu ; Michael K. Skinner
- 关键词：Epigenetics ; Transgenerational ; Environmental exposures ; Reproduction ; Systems biology ; Development
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2012
- 期刊代码：109_03037207
- 类别：bio
- 出版时间：6 May, 2012
- 卷：354
- 期：1-2
- 页码：3-8
- 文件大小：242 K
摘要
Environmental epigenetics has an important role in regulating phenotype formation or disease etiology. The ability of environmental factors and exposures early in life to alter somatic cell epigenomes and subsequent development is a critical factor in how environment affects biology. Environmental epigenetics provides a molecular mechanism to explain long term effects of environment on the development of altered phenotypes and 鈥渆mergent鈥?properties, which the 鈥済enetic determinism鈥?paradigm cannot. When environmental factors permanently alter the germ line epigenome, then epigenetic transgenerational inheritance of these environmentally altered phenotypes and diseases can occur. This environmental epigenetic transgenerational inheritance of phenotype and disease is reviewed with a systems biology perspective.