The biology of EBV infection in human epithelial cells

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• 作者：Sai Wah Tsao^a ; ^{gswtsao@hkucc.hku.hk} ; Chi Man Tsang^a ; Pei Shin Pang^a ; Guitao Zhang^a ; Honglin Chen^b ; Kwok Wai Lo^c
• 关键词：EBV ; Biology of infection ; Epithelial cells ; Nasopharyngeal carcinoma
• 刊名：Seminars in Cancer Biology
• 出版年：2012
• 期刊代码：308_1044579x
• 类别：med
• 出版时间：April, 2012
• 卷：22
• 期：2
• 页码：137-143
• 文件大小：530 K

摘要

EBV-associated human malignancies may originate from B cells and epithelial cells. EBV readily infects B cells in vitro and transforms them into proliferative lymphoblastoid cell lines. In contrast, infection of human epithelial cells in vitro with EBV has been difficult to achieve. The lack of experimental human epithelial cell systems for EBV infection has hampered the understanding of biology of EBV infection in epithelial cells. The recent success to infect human epithelial cells with EBV in vitro has allowed systematic investigations into routes of EBV entry, regulation of latent and lytic EBV infection, and persistence of EBV infection in infected epithelial cells. Understanding the biology of EBV infection in human epithelial cells will provide important insights to the role of EBV infection in the pathogenesis of EBV-associated epithelial malignancies including nasopharyngeal carcinoma and gastric carcinoma.