Alcohol drinking and epithelial ovarian cancer risk. A systematic review and meta-analysis

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• 作者：Matteo Rota^a ; ^b ; ^{matteo.rota@unimib.it} ; Elena Pasquali^b ; Lorenza Scotti^b ; Claudio Pelucchi^c ; Irene Tramacere^c ; Farhad Islami^d ; ^e ; ^f ; Eva Negri^c ; Paolo Boffetta^f ; ^g ; Rino Bellocco^b ; ^h ; Giovanni Corrao^b ; Carlo La Vecchia^c ; ⁱ ; Vincenzo Bagnardi^b ; ^j
• 关键词：Alcohol-drinking ; Dose&ndash ; risk relation ; Meta-analysis ; Epithelial ovarian cancer
• 刊名：Gynecologic Oncology
• 出版年：2012
• 期刊代码：295_00908258
• 类别：med
• 出版时间：June, 2012
• 卷：125
• 期：3
• 页码：758-763
• 文件大小：618 K

摘要

Objective

In order to provide an updated quantification of the association between alcohol drinking and epithelial ovarian cancer risk, we conducted a meta-analysis of published observational studies.

Methods

Using PubMed, we performed a literature search of all case-control and cohort studies published as original articles in English up to September 2011. We included 27 observational studies, of which 23 were case-control studies, 3 cohort studies and one pooled analysis of prospective cohort studies, including a total of 16,554 epithelial ovarian cancer cases. We derived pooled meta-analytic estimates using random-effects models.

Results

The pooled relative risk (RR) for any alcohol drinking compared with non/occasional drinking was 1.00 [95%confidence interval (CI), 0.95-1.05]. The RRs were 0.97 (95%CI, 0.92-1.02), 1.03 (95%CI, 0.96-1.11) and 1.09 (95%CI, 0.80-1.50) for light (鈮?#xA0;1 drink/day), moderate (> 1 to < 3 drinks) and heavy drinking (鈮?#xA0;3 drinks/day), respectively. In particular, the pooled RR for invasive epithelial ovarian cancers was 1.00 (95%CI, 0.95-1.06), while for borderline cancers was 0.96 (95%CI, 0.74-1.26). Stratified analyses across cancer histotypes revealed a modest protective effect of alcohol on endometrioid epithelial ovarian tumors (RR = 0.82, 95%CI, 0.70-0.96), while no association was found for serous (RR = 1.00, 95%CI, 0.84-1.19), mucinous (RR = 0.91, 95%CI, 0.78-1.08) and clear cell (RR = 0.93, 95%CI, 0.76-1.14) cancers. There was no evidence of publication bias.

Conclusions

This comprehensive meta-analysis provided no evidence of a material association between alcohol drinking and epithelial ovarian cancer risk.