Jagged1 and Notch1 help edit M cell patterning in Peyer鈥檚 patch follicle epithelium

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• 作者：En-Hui Hsieh ; David D. Lo ; ^{david.lo@ucr.edu}
• 关键词：PPFAE ; Peyer&rsquo ; s patch follicle associated epithelium ; Dll1 ; Delta-like 1 ; UEA-1 ; Ulex Europeus Agglutinin-1 ; PGRP-S ; Peptidoglycan Recognition Protein-S
• 刊名：Developmental and Comparative Immunology
• 出版年：2012
• 期刊代码：35_0145305x
• 类别：abs
• 出版时间：June, 2012
• 卷：37
• 期：2
• 页码：306-312
• 文件大小：1369 K

摘要

Mucosal epithelium M cells are dispersed across Peyer鈥檚 patch follicle associated epithelium (PPFAE) with minimal clustering. Since Notch signaling can influence patterning in epithelia, we examined its influence on PPFAE M cell distribution. Conditional deletion of Notch1 in intestinal epithelium increased PPFAE M cells and also increased M cell clustering, implying a role for Notch in both M cell numbers and lateral inhibition. By contrast, conditional deletion of the ligand Jagged1 also increased M cell clustering, but with a paradoxical decrease in M cell density. In vitro, inhibition of Notch signaling reduced expression of an M cell associated gene CD137, consistent with cis-promoting effects on M cell development. Thus, Jagged1 may have a cis-promoting role in committed M cells, but a trans-inhibitory effect on neighboring cells. In sum, Jagged1-Notch signaling may edit the pattern of M cells across the PPFAE, which may help optimize mucosal immune surveillance.