• 作者：Antoni Sicras Mainar^a ; ^{asicras@bsa.cat} ; Ruth Navarro Artieda^b ; Silvia Dí ; az Cerezo^c ; Belé ; n Martí ; Sá ; nchez^c ; ¹ ; Veró ; nica Sanz De Burgoa^d
• 关键词：Tabaquismo ; Cesació ; n ; Vareniclina ; Bupropió ; n ; Terapia sustitutiva con nicotina
• 刊名：Atenci贸n Primaria
• 出版年：2011
• 期刊代码：pca69_02126567
• 类别：med
• 出版时间：September 2011
• 卷：43
• 期：9
• 页码：482-489
• 文件大小：202 K

Objective

The objective of this study was to estimate the continuous abstinence rates of varenicline, bupropion and nicotine replacement therapy (NRT) in smoking cessation in 2 Primary Care (PC) External Support Units.

Design

Observational, multicentre, longitudinal study using a retrospective review of medical records.

Setting

Six Primary Care Centres.

Participants

Patients > 18 years, who began smoking cessation treatment between 1/01/2006 and 1/12/2008 with varenicline, bupropion or NRT were included in the analysis.

Continuation

Patient follow-up was conducted from time-baseline (day 1) and assessed at 6 and 12 months. Main variables: comorbidities, effectiveness (continuous abstinence) and pharmacological tolerability. Statistical analysis: logistic regression models and Kaplan-Maier survival curves; P < .05.

Results

A total of 957 smokers treated with NRT (53.0%), bupropion (25.1%) and varenicline (21.9%) were included in the analysis. Mean age: 47.6 (11.3) years; 58.6%men. 32.0%of smokers attended due to physical dependence. Average duration of smoking: 19.5 (6.7) years. At 6 months, 61.2%(95%CI: 54.6-67.8%) of participants in the varenicline group continuously abstained from smoking compared with 56.9%(95%CI: 50.6-63.2%) in the bupropion group, and 52.3%(95%CI: 48.0-56.6%) in the NRT group; P = .003. At 12 months, the rate of continuous abstinence was 57.4%(95%CI: 50.7-64.1%) in the varenicline group compared with 52.9%(95%CI: 46.6-59.2%) in the bupropion group and 47.1%(95%CI: 42.8-51.4%) in the NRT group; P = .002.

Conclusion

One year-follow up results suggest that varenicline is an appropriate alternative compared with bupropion and NRT on smoking cessation in the PC setting.