An ORS-ICP-MS method for monitoring trace levels of cobalt and chromium in whole blood samples from hip arthroplasty patients with metal-on-metal prostheses

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• 作者：K.L. Pei^a ; D.W. Kinniburgh^a ; ^{dkinnibu@ucalgary.ca} ; L. Butlin^a ; P. Faris^b ; D. Lee^c ; D.A. Marshall^b ; ^d ; M.C. Oliver^c ; R. Parker^b ; J.N. Powell^c ; P. Railton^c ; J. Smith^c
• 关键词：Hip arthroplasty ; Chromium ; Cobalt ; ICP-MS ; Inductively coupled plasma mass spectrometry ; Metal-on-metal ; Octopole reaction cell ; ORS-ICP-MS ; Trace metal ; Whole blood
• 刊名：Clinical Biochemistry
• 出版年：2012
• 期刊代码：55_00099120
• 类别：med
• 出版时间：July, 2012
• 卷：45
• 期：10-11
• 页码：806-810
• 文件大小：288 K

摘要

Objective

To develop a rapid and reliable method, using an octopole reaction system (ORS) ICP-MS, capable of monitoring trace levels of Co and Cr in whole blood samples from hip arthroplasty patients with metal-on-metal prostheses.

Design and method

Whole blood is diluted 10-fold with an alkaline diluent and analyzed using an Agilent 7500 CE ORS-ICP-MS.

Results

Limit of quantification of 0.03 渭g/L Co and 0.20 渭g/L Cr in patient samples. < 6%covariance obtained for quality control materials analyzed over 10 runs.

Conclusion

This method is capable of monitoring trace levels of Co and Cr in diluted whole blood samples with a vial to vial run time of approximately 2 min. Results are comparable to those obtained using high resolution (HR) ICP-MS with sample digestion.