• 作者：Gerardo Atienza Merino ^{gerardo.atienza.merino@sergas.es}
• 关键词：Ganglio centinela ; Cá ; ncer de vulva ; Linfadenectomí ; a ; Sensibilidad y especificidad ; Recurrencia
• 刊名：Progresos de Obstetricia y Ginecolog铆a
• 出版年：2010
• 期刊代码：pca294_03045013
• 类别：med
• 出版时间：October 2010
• 卷：53
• 期：10
• 页码：403-411
• 文件大小：169 K

Objectives

To assess the percentage detection of sentinel-lymph-node in vulval cancer, its sensitivity and negative predictive value (NPV). To ascertain the adverse effects of this technology and long term relapses of tumour.

Material and methods

Systematic review of literature and subsequent critical appraisal of the evidence.

Results

A total of 29 studies were selected, all of which were observational in nature. The sentinel lymph node was detected by Tc⁹⁹-colloid and combined technique in 98%of patients. The percentage of false negatives observed was less than 2%, the sensitivity values and NPV were over 95%and the lymph node relapse rate around 3%.

Conclusions

Sentinel-lymph-node technique would seem to be a reasonable alternative to inguinal lymphadenectomy in patients with early stages of vulval cancer. When it comes to implementing the technique, a series of factors must be borne in mind with respect to the work team, patient selection, detection technique, surgical and anatomopathological techniques and learning curve.