• 作者：Emilio Má ; rquez Contreras^a ; ^{emarquezc@papps.org} ; Nieves Martel Claros^b ; Vicente Gil Guillé ; n^c ; José ; Luis Mart&#237 ; n De Pablos^a ; Mariano De la Figuera Von Wichman^d ; José ; Joaqu&#237 ; n Casado Mart&#237 ; nez^a ; Jacinto Espinosa Garc&#237 ; a^e ; José ; Carlos Pastoriza Vilas^f
• 关键词：Hipertensió ; n arterial ; Cumplimiento farmacoló ; gico ; Ensayo clí ; nico ; Atenció ; n primaria ; Revista educacional
• 刊名：Atenci贸n Primaria
• 出版年：2009
• 期刊代码：pca69_02126567
• 类别：med
• 出版时间：September 2009
• 卷：41
• 期：9
• 页码：501-510
• 文件大小：454 K

Objetive

To evaluate the efficacy of an intervention by means of an educational magazine on treatment compliance in uncontrolled arterial hypertension (AHT).

Design

Controlled, randomised clinical trial.

Setting

87 primary care centres. Spain.

Participants

A total of 450 patients with uncontrolled hypertension were included.

Intervention

Two groups of 225 patients were formed: 1) Control group (CG): standard health intervention; 2) Intervention Group (IG): received a twice monthly educational magazine at home.

Main measurements

Compliance was measured using the Medication Event Monitoring System (MEMS-Aardex). Compliance rate (CR) was recorded. Compliers were defined as individuals with a treatment compliance of 80鈥?10%. The percentage of compliers, the mean percentage of doses taken and the percentage of patients taking the medication at the correct times were estimated. The mean blood pressures (BPs) and the percentage of controlled patientswere calculated. The number needed to treat (NNT) was calculated.

Results

A total of 393 individuals were evaluable (Age: 62.4 years), 196 in the IG and 197 in the CG. There were 83.2%(95%CI 78鈥?8.4) and 49.2%(95%CI 42.2鈥?6.2) (P=0.0001) of overall compliers in the IG and CG, respectively and 74%(95%CI: 67.9鈥?0.1) and 42.6%(95%CI=35.7鈥?9.5) (P=0.0001) of correct times compliers. A total of 81.6%(95%CI=76.2鈥?6.5%)) were controlled in the IG and 56.3%(95%CI=49.4鈥?3.2) in the CG. The NNT was 3.3 patients.

Conclusions

Therapeutic non-compliance was very high. The educational magazine is an effective strategy to improve the compliance and degree of control of the AHT.