Ten men with T2DM underwent four 1-h exercise sessions at 60%of their maximal oxygen uptake (VO2max) under the following conditions: 1) fasting (F), and 2) 2聽h postprandial (PP) without medication; and 3) fasting (F-Atenolol), and 4) 2聽h postprandial (PP-Atenolol) after a one-week treatment with atenolol. Results were tested for the effects of atenolol via two-way ANOVA for the F vs F-Atenolol and PP vs PP-Atenolol states separately. Atenolol treatment decreased fasting and postprandial glycerol (p聽<聽0.0001) and NEFA (p聽<聽0.0001), postprandial epinephrine (p聽=聽0.048), postprandial cortisol (p聽=聽0.02), postprandial ASP (p聽=聽0.04) and postprandial dopamine (p聽<聽0.004).
Atenolol alters fatty acid metabolism and associated metabolic hormones including ASP during exercise in men with T2DM and its effects are more apparent during conditions of stress such as the postprandial state, acute exercise and obesity.