- 作者：Kyung Ah Kim ; Myeong-Jin Kim ; kimnex@yuhs.ac ; kimnex@yumc.yonsei.ac.kr ; Jin-Young Choi ; Yong Eun Chung
- 关键词：Hepatocellular carcinoma ; Liver cirrhosis ; Ultrasound ; Surveillance ; Hepatitis B
- 刊名：European Journal of Radiology
- 出版年：2012
- 期刊代码：93_0720048x
- 类别：med
- 出版时间：July, 2012
- 卷：81
- 期：7
- 页码：1450-1454
- 文件大小：801 K
Background
To evaluate hepatocellular carcinoma (HCC) that developed in patients with no evidence of a tumor during a prior ultrasound (US) performed within 1 year of the diagnosis.Methods
We retrospectively analyzed data for 100 consecutive patients with liver cirrhosis who had undergone US within 1 year prior to HCC diagnosis and who showed no liver lesions on the previous US. Size and T stage of HCC were assessed as well as whether patients met surgical criteria for liver transplantation as HCC treatment [Milan or University of California at San Francisco (UCSF) criteria].
Results
The mean interval between the negative and diagnostic scans was 5 months, 13 days. HCC presented as a single nodule in 69 patients (size, 0.8-8.0 cm), as two or more nodules in 18 patients, and as the diffuse form of HCC in 13 patients. HCC presented as a small tumor (<3 cm) in 48 patients. T stages were: T1 in 26 patients, T2 in 45, T3 in 18, and T4 in 11. The Milan criteria were met in 79 patients. Eighty-five patients fulfilled the UCSF.
Conclusion
Patients may present with advanced HCC, even if sonographic findings were negative within 1 year prior to diagnosis.