UTE-T2鈭?mapping detects sub-clinical meniscus injury after anterior cruciate ligament tear

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• 作者：A. Williams^&dagger ; ; ^{williamsaa@upmc.edu} ; Y. Qian^&Dagger ; ; ^{qiany@upmc.edu} ; S. Golla^&dagger ; ; ^§ ; ; ^{gollsk@upmc.edu} ; C.R. Chu^&dagger ; ; ^鈥?/sup> ; ^{chucr@upmc.edu}
• 关键词：Meniscus ; MRI ; UTE ; Osteoarthritis
• 刊名：Osteoarthritis and Cartilage
• 出版年：2012
• 期刊代码：249_10634584
• 类别：med
• 出版时间：June, 2012
• 卷：20
• 期：6
• 页码：486-494
• 文件大小：1125 K

摘要

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Summary

Objective

Meniscus tear is a known risk factor for osteoarthritis (OA). Quantitative assessment of meniscus degeneration, prior to surface break-down, is important to identification of early disease potentially amenable to therapeutic interventions. This work examines the diagnostic potential of ultrashort echo time-enhanced T2鈭?(UTE-T2鈭? mapping to detect human meniscus degeneration in聽vitro and in聽vivo in subjects at risk of developing OA.

Design

UTE-T2鈭?maps of 16 human cadaver menisci were compared to histological evaluations of meniscal structural integrity and clinical magnetic resonance imaging (MRI) assessment by a musculoskeletal radiologist. In聽vivo UTE-T2鈭?maps were compared in 10 asymptomatic subjects and 25 ACL-injured patients with and without concomitant meniscal tear.

Results

In聽vitro, UTE-T2鈭?values tended to be lower in histologically and clinically normal meniscus tissue and higher in torn or degenerate tissue. UTE-T2鈭?map heterogeneity reflected collagen disorganization. In聽vivo, asymptomatic meniscus UTE-T2鈭?values were repeatable within 9%(root-mean-square average coefficient of variation). Posteromedial meniscus UTE-T2鈭?values in ACL-injured subjects with clinically diagnosed medial meniscus tear (n = 10) were 87%higher than asymptomatics (n = 10, P < 0.001). Posteromedial menisci UTE-T2鈭?values of ACL-injured subjects without concomitant medial meniscal tear (n = 15) were 33%higher than asymptomatics (P = 0.001). Posterolateral menisci UTE-T2鈭?values also varied significantly with degree of joint pathology (P = 0.001).

Conclusion

Significant elevations of UTE-T2鈭?values in the menisci of ACL-injured subjects without clinical evidence of subsurface meniscal abnormality suggest that UTE-T2鈭?mapping is sensitive to sub-clinical meniscus degeneration. Further study is needed to determine whether elevated subsurface meniscus UTE-T2鈭?values predict progression of meniscal degeneration and development of OA.