Two genetic variants in FABP1 and susceptibility to non-alcohol fatty liver disease in a Chinese population

详细信息	查看全文 | 推荐本文 |

• 作者：Xian-E Peng^a ; ^b ; ¹ ; Yun-Li Wu^a ; ^c ; ¹ ; Qing-Qing Lu^d ; Zhi-Jian Hu^b ; Xu Lin^a ; ^c ; ^{linxu@mail.fjmu.edu.cn}
• 关键词：ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; BMI ; body mass index ; CI ; confidence interval ; DABP ; diastolic arterial blood pressure ; DF ; degrees of freedom ; FABP1 ; liver fatty acid-binding protein ; FPG ; fasting plasma glucose ; HDL-C ; hi
• 刊名：Gene
• 出版年：2012
• 期刊代码：73_03781119
• 类别：bio
• 出版时间：25 May, 2012
• 卷：500
• 期：1
• 页码：54-58
• 文件大小：194 K

摘要

Liver fatty acid-binding protein (FABP1) serves as a key regulator of hepatic lipid metabolism, and polymorphisms within the <em>FABP1em> gene have been associated with several metabolic traits. To investigate the association between <em>FABP1em> polymorphisms and the risk of non-alcohol fatty liver disease (NAFLD) in a Chinese population, the genotypes and haplotypes of <em>FABP1em> (rs2241883 T/C and rs1545224G/A) were determined in 553 patients with NAFLD and 553 healthy controls. The results showed that individuals with at least one copy of the rs2241883 C allele (TC or CC genotype) had an elevated risk for developing NAFLD (odds ratio [OR] = 1.32, 95%CI: 1.01-1.71), and individuals with at least one copy of the rs1545224 A allele (GA or AA genotype) also had a significantly increased risk for NAFLD (OR = 1.52, 95%CI: 1.14-2.02). Cumulative effect analysis of the two SNPs revealed that individuals with two risk genotypes were at significantly higher risk of NAFLD than those without risk genotype, and a significant trend of increased risk with increasing numbers of risk genotype was observed. Stratification analysis showed that the rs2241883 C allele carriers had higher level of LDL-C and the rs1545224 A allele carriers had higher level of FPG than those without this allele. In addition, haplotype analysis revealed that the one composed of the rs1545224 A and rs2241883 C variants was significantly associated with an increased risk for NAFLD (OR = 1.34; 95%CI = 1.05-1.40) compared to the GT haplotype. Taken together, the present study suggests that genetic variations within <em>FABP1em> influence susceptibility to NAFLD independently or jointly.