A review of intestinal fatty acid binding protein gene variation and the plasma lipoprotein response to dietary components
- 作者：Hegele ; Robert A.
- 关键词：lipids ; nutrition ; genetics ; DNA analysis
- 刊名：Clinical Biochemistry
- 出版年：1998
- 期刊代码：55_00099120
- 类别：med
- 出版时间：November, 1998
- 卷：31
- 期：8
- 页码：609-612
- 文件大小：175 K
摘要
Objectives: Because there is interindividual variation in the metabolic response to diet, it important to find and evaluate candidate genes, which have common functional variants in the general population, and which may be determinants of interindividual differences in the response to components of the diet, such as dietary fat and fiber. One such candidate gene is FABP2, which encodes the intestinal fatty acid binding protein. This gene has a common variation in the coding sequence, which results in either alanine or threonine to be translated at residue 54. This amino acid variation has an in vitro functional impact. In addition, there have been several published associations with metabolic phenotypes, such as impaired glucose tolerance, obesity, altered plasma lipids and lipoproteins.