CD105 and placental growth factor - Potent prognostic factors in childhood acute lymphoblastic leukaemia

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• 作者：Patrycja Sujka-Kordowska^a ; Agnieszka Malinska^a ; Danuta Ostalska-Nowicka^b ; Maciej Zabel^a ; Michal Nowicki^a ; ^{mnowicki@ump.edu.pl}
• 关键词：CD105 ; Placental growth factor ; Acute lymphoblastic leukaemia ; Prognosis
• 刊名：Leukemia Research
• 出版年：2012
• 期刊代码：186_01452126
• 类别：med
• 出版时间：July, 2012
• 卷：36
• 期：7
• 页码：846-851
• 文件大小：1265 K

摘要

The studies aimed at identifying a prognostic significance of angiogenesis-related factors: CD105 and placental growth factor (PlGF) in a course of acute lymphoblastic leukaemia (ALL). Research protocol was based on detection of RNA and protein expressions in bone marrow blasts using quantitative PCR and immunocytochemical assays respectively.

Kaplan-Meier statistics revealed CD105 and PlGF expression as managed separately do not correlate with relapse-free time in ALL patients. On the other hand, an associated analysis of CD105 and PlGF demonstrated a significantly shorter progression-free time in children who were CD105+ and PlGF+ or CD105鈭?and PlGF+ at the moment of ALL diagnosis.