Dehydroepiandrosterone-sulfate as a biomarker of senescence in male non-human primates
- 作者：Muehlenbein ; Michael P. ; Campbell ; Benjamin C. ; Richards ; Robert J. ; Svec ; Frank ; Phillippi-Falkenstein ; Kathrine M. ; et. al.
- 关键词：Dehydroepiandrosterone-sulfate ; Dehydroepiandrosterone ; Cortisol ; Senescence ; Adrenal function ; Macaca mulatta ; Macaca nemestrina ; Papio cynocephalus
- 刊名：Experimental Gerontology
- 出版年：2003
- 期刊代码：99_05315565
- 类别：med
- 出版时间：October, 2003
- 卷：38
- 期：10
- 页码：1077-1085
- 文件大小：171 K
摘要
Numerous studies have suggested important and varying roles for dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S) in primate physiological functions. Despite these numerous claims, specific actions and significance of DHEA and DHEA-S are still equivocal. A decline of these hormones in adult humans may have functional significance, yet there is no clear relationship between functional impairments of aging and the decline in DHEA or DHEA-S levels. This current study attempts to address the natural history of adrenal hormones by presenting non-human primate evidence of the endocrinology of aging; the age-related patterns of adrenal hormone decline in three species of the subfamily Cercopithecinae, Macaca mulatta, Macaca nemestrina, and Papio cynocephalus are compared. It is concluded that DHEA-S and cortisol represent lineage specific markers of senescence among primates and that parallel age-related patterns of DHEA-S and cortisol likely reflect lineage specific effects, or rather, phylogenetic similarities of endocrine senescence. The use of relative adrenal hormone levels to approximate species' life expectancies is discussed.