Behavioral effects of 26RFamide and related peptides

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• 作者：Jean-Claude do Rego ; Jé ; rô ; me Leprince ; Nicolas Chartrel ; Hubert Vaudry and Jean Costentin
• 刊名：Peptides
• 出版年：2006
• 期刊代码：59_01969781
• 类别：neu
• 出版时间：November 2006
• 卷：27
• 期：11
• 页码：2715-2721
• 文件大小：378 K

摘要

A novel 26-amino acid peptide possessing the Arg–Phe–NH₂ motif at its C-terminal extremity has been recently characterized and named 26RFamide (26RFa). The 26RFa precursor encompasses several potential cleavage sites and thus may generate various mature peptides including an N-terminally extended form of 26RFa (termed 43RFa), two fragments of 26RFa (26RFa_1–16 and 26RFa_20–26), and a 9-amino acid peptide (9RFa) located in tandem in the human 26RFa precursor. In the present study, we have investigated the central effects of 26RFa and related peptides on food intake and locomotor activity in mice. We observed that i.c.v. injection of 26RFa, 43RFa, 26RFa_20–26 and 9RFa stimulated food consumption while 26RFa_1–16 and 26RFa_8–16 had no effect. A dose-dependent stimulation of locomotor activity was observed after i.c.v. administration of 26RFa, 43RFa and 26RFa_1–16, but not 26RFa_20–26, 26RFa_8–16 or 9RFa. These data indicate that the novel neuropeptides 26RFa and 43RFa act centrally to stimulate feeding and locomotor activities but the domains of the peptide involved in each of these responses are different suggesting that the two behavioral effects may be mediated through distinct receptors.