Synthesis, characterization and antitumor activity of novel amide derivatives containing ferrocenyl pyrazol-moiety

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• 作者：Xian-Feng Huang^a ; Jian-Feng Tang^b ; Jun-Ling Ji^a ; Xiao-Liang Wang^b ; Ban-Feng Ruan^b ; ^{bf_ruan@163.com}
• 关键词：Ferrocene-containing acetic acid ; Amide derivative ; X-ray structural analysis ; Antitumor activity
• 刊名：Journal of Organometallic Chemistry
• 出版年：2012
• 期刊代码：64_0022328x
• 类别：ch
• 出版时间：1 June, 2012
• 卷：706-707
• 期：Complete
• 页码：113-123
• 文件大小：3072 K

摘要

A series of novel 2-(5-ferrocenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-N-amide derivatives (1-38) were prepared. The compounds were characterized by ¹H NMR, ¹³C NMR, IR, mass spectroscopy and element analysis. Compounds 19 and 30 were also gave crystals suitable for X-ray structural analysis. Biological evaluation of all the compounds were performed in the human prostatic carcinoma cell line (PC-3) and human mammary carcinoma cell line (Bcap-37) using the MTT method. Among them, compound 10 exhibited comparable in聽vitro antitumor activity to the positive control 5-Fluorouracil (5-FU) and cisplatin.