• 作者：J. Paz Aparicio^a ; ^{jose_paz6@hotmail.com} ; E. Ló ; pez-Anglada Fern&#225 ; ndez^a ; H. Montes Prieto^b ; J. Pena V&#225 ; zquez^a ; I. Fern&#225 ; ndez Bances^a ; V. Folgueras Henriksen^a ; P. Ló ; pez Fern&#225 ; ndez^a ; J.C. Ló ; pez-Fanjú ; l Mené ; ndez^a ; E. Valle Garay^b ; V. Asensi Á ; lvarez^c
• 关键词：Hernia discal lumbar ; Polimorfismo gené ; tico ; Citocinas ; &Oacute ; xido ní ; trico sintasa
• 刊名：Revista Espa帽ola de Cirug铆a Ortop茅dica y Traumatolog铆a
• 出版年：2010
• 期刊代码：pca311_18884415
• 类别：med
• 出版时间：July-August 2010
• 卷：54
• 期：4
• 页码：227-233
• 文件大小：189 K

Objective

To evaluate the association between the presence of the genotype of certain genetic polymorphisms (GP) of the cytokine and oxide nitric synthase (NOS) and the development of lumbar herniated disc (LHD).

Materials and methods

We reviewed 179 patients in a retrospective case-control study. The case group was made up of 50 patients with confirmed lumbar herniated disc diagnosed by Magnetic Resonance Imaging (MRI). The control group was made up of patients admitted for hip and knee prosthetic surgery who did not have or had not had any symptoms consistent with LHD. Blood was drawn from all of the study participants. The genotypes of the GP were obtained of the cytokines to be studied: Interleukin-1 [IL-1伪(鈭?89 C/T), IL-1尾(+3953 T/C)], Tumor Necrosis Factor-伪 [TNF-伪 (鈭?08 G/A) and (鈭?38G/A)].

Results

The CC genotype and C allele frequency of the IL-1尾 PG (+3953T/C) polymorphism were significantly more frequent in patients with LDH compared to the controls. On the contrary, the control group patients carried eNos GPs (鈭?68 T/C) and iNOS22 G/A polymorphisms more frequently than the LHD group, this difference being statistically different for both polymorphisms.

Conclusions

We found that individuals who were carriers of the CC genotype of the IL-1b(+3953T/C) polymorphism showed higher susceptibility to suffer lumbar disc herniation. Furthermore, being a carrier of ENOS (鈭?86 T/C) and iNOS (22 G/A) polymorphisms suggests that this could behave as a protection factor against disc herniation.