Risk assessment associated to the intake of the emerging Fusarium mycotoxins BEA, ENs and FUS present in infant formula of Spanish origin

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• 作者：A.B. Serrano ; ^{a.belen.serrano@uv.es} ; G. Meca ; G. Font ; E. Ferrer
• 关键词：Enniatins ; Beauvericin ; Fusaproliferin ; Fusarium spp. ; Infant formula ; Risk assessment
• 刊名：Food Control
• 出版年：2012
• 期刊代码：49_09567135
• 类别：abs
• 出版时间：November, 2012
• 卷：28
• 期：1
• 页码：178-183
• 文件大小：280 K

摘要

Forty-five samples of Spanish follow-up infant formula with different chemical compositions were analyzed determining the emerging Fusarium mycotoxins beauvericin (BEA), enniatins (ENs) (A, A₁, B, B₁), and fusaproliferin (FUS). The samples were extracted three times with ethyl acetate using an Ultra-turrax homogenizer. Mycotoxins were identified and quantified using a liquid chromatography (LC) coupled to a diode array detector (DAD). Results showed that the percentage of the samples contaminated with ENs and FUS were 46.6 and 20.0%respectively, whereas all analyzed samples were free of BEA. The ENs A and B were detected only in one sample with 149.6 and 39.4聽mg/kg respectively. The ENB₁ was the more detected mycotoxin with levels ranging from 11.4 to 41.9聽mg/kg. The ENA₁ was detected at levels ranging from 6.3 to 101.7聽mg/kg. The minor Fusarium mycotoxin FUS was detected in a range variable from 0.7 to 1.7聽mg/kg. Finally, dietary exposure of Spanish infants (between 6 and 12 months) to ENs, BEA and FUS, was estimated through the consumption of commercial follow-up infant formula by the calculation of the estimated daily intake (EDI). Considering the sum of the mycotoxins studied, the data evidenced that the EDI was 236.2聽渭g/kg聽bw/day.