• 作者：Manuel Muñ ; oz^a ; José ; A. Garcí ; a-Erce^b ; ^{joseerce@vodafone.es} ; Ana I. Dí ; ez-Lobo^c ; Arturo Campos^d ; Carmen Sebastianes^e ; Elvira Bisbe^f ; Anaemia Working Group Españ ; a (AWGE)
• 关键词：Anemia preoperatoria ; Ferropenia ; Cirugí ; a mayor ; Hierro intravenoso
• 刊名：Medicina Cl铆nica
• 出版年：2009
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：7 March 2009
• 卷：132
• 期：8
• 页码：303-306
• 文件大小：169 K

Background and objective

There is a high incidence of perioperative anemia among surgical patients (20%鈥?0%). Preoperative anemia has been linked to an increased postoperative morbidity and mortality, as well as a decreased quality of life of surgical patients. In addition, a low preoperative hemoglobin constitutes an important predictive factor of allogeneic blood transfusion in major surgery. We evaluated the efficacy of intravenous iron sucrose (IVIS) administration for correction of anemia in these patient populations.

Patients and method

Data from 84 patients with anemia who were scheduled for major elective surgery (30 colon cancer resections, 33 abdominal hysterectomies, 21 lower limb arthroplasties) and who received preoperative IVIS during 3鈥? weeks were propectively collected.

Results

Administration of IVIS 鈥攎ean dose (standard deviation): 1000 (440) mg鈥?caused a significant increase of hemoglobin levels 鈥?.0 (1.6) g/dl (p<0.001)鈥?and anemia was resolved in 58%of patients. No life-threatening adverse effect was witnessed.

Conclusions

Because of the low incidence of side effects and the rapid increase of hemoglobin levels, IVIS emerges as a safe, effective drug for treating preoperative anemia in these patient populations.